Extreme Risk Protection Orders (ERPOs), also known as Gun Violence Restraining Orders in California, are intended to prevent gun violence by temporarily removing firearms from individuals judged to be at risk of self-harm or harming others. We use data from the Longitudinal Study of Handgun Ownership and Transfer—a statewide cohort of over 38 million registered voters in California from 2004 to 2021—to examine the effects of ERPOs on suicide risk among handgun owners using a difference-in-differences design. We find that ERPOs provide a modest protective effect on suicide risk (risk difference: –4.2 suicide deaths per 100,000 handgun owners; 95% confidence interval: –9.7, 1.25). Our event-study analysis suggests that suicide risk among handgun owners remains relatively stable in the post-ERPO period, even as the number of ERPOs increased. Importantly, our findings apply to handgun owners and should not be interpreted as evidence that ERPOs had no effects in the group actually targeted by these orders. This study provides the first individual-level evidence on the effects of ERPOs.